Philip Hahnfeldt, PhD
Center of Cancer Systems Biology
Email: hahnfeldt [at] cancer-systems-biology.org
Philip Hahnfeldt is Senior Investigator in the Center of Cancer Systems Biology and was an Associate Professor of Medicine, Tufts University School of Medicine. He joined the CCSB at its founding from the Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School. He graduated from MIT in Applied Mathematics and went on to attend graduate school under a National Science Foundation Fellowship. He was awarded his doctorate at MIT in 1991 while receiving biomedical training at the Yale University School of Medicine. His dissertation, “The Suitability and Formulation of a Continuous-Time, Markov Chain Approach to Cellular DNA Radiation Damage and Repair”, investigated chromosome-level kinetic responses to ionizing radiation bearing on cell killing and oncogenic transformation. Dr. Hahnfeldt continued and expanded on these investigations as a Research Associate, then as Instructor at the Joint Center for Radiation Therapy, Harvard Medical School. He was appointed Assistant Professor in Radiation Oncology at Harvard Medical School and worked with the Chief Resident in Radiation Oncology to organize and teach the training program for residents, serving as course instructor from 1999–2001.
Dr. Hahnfeldt's interests span four major subdisciplines in cancer biology:
- modeling of DNA damage and repair, relating these to chromosome geometry;
- theoretically describing the kinetics of tumor growth suppression under anti-angiogenic therapy;
- examining how intra-tumor heterogeneity is expressed and may be defeated; and
- exploring the role of inter-tissue interactions in carcinogenesis.
The chromosome damage/repair studies have interrelated results on cytogenetics and interphase chromosome localization and geometry. By developing a revised theory for double-strand break repair/misrepair following ionizing radiation, Dr. Hahnfeldt found it possible to improve upon the commonly-accepted repair models, in the process obtaining information on how chromosomes are packaged within the nucleus. Incomplete exchange models developed from these studies were also able to explain the relation between acentric and dicentric counts and the excess dispersion (variance/mean) for the number of acentric fragments relative to dicentrics seen in human lymphocytes exposed to various radiation types and doses.
As a second research focus, extending from collaboration with the late Dr. Judah Folkman of Children's Hospital, Boston, Dr. Hahnfeldt is exploring the unique tumor/vascular regression kinetics of anti-angiogenic therapy. The indirect means by which tumor suppression is here accomplished, coupled with the recent finding that tumors both stimulate and inhibit their own vascularization, points to a need to formulate tumor-vascular models that properly capture the dynamics. Dr. Hahnfeldt has undertaken to do this, using sets of differential equations that simultaneously consider vascular response to anti-angiogenic agents and subsequent suppression of tumor growth. The result is a formalism that is proving to be both explanatory and clinically predictive. This work is an example of quantitative translational research, a “workstation-to-bench-to-bedside” research strategy embraced by the CCSB. An important dynamic to surface from these studies is the self-imposed Gompertz restriction on growth imposed by a tumor on itself. Implications for the general organogenic control of tissue mass are suggested. Another study of dose rate effects addresses an as yet un-quantified effect — the utility of so-called “metronomic” (small, evenly-spaced) dosing on the treatment response of a tumor population (Benzekry & Hahnfeldt, 2013). It was shown considering the response of a heterogeneous target to various dosing protocols that: 1) metronomic dosing does indeed offer the best tumor suppression, and 2) the shift to metronomic dosing from more traditional “up-front” dosing regimens favors the endothelial cell compartment. The theory offers one explanation for numerous reports of an antiangiogenic response using the metronomic scheme.
A unifying theme in both the DNA repair and angiogenesis studies is the role tumor heterogeneity and inter-tissue interactions play in carcinogenesis risk (under DOE funding) and cancer treatment response (through the NCI's Integrative Cancer Biology Program [ICBP]). Dr. Hahnfeldt is currently employing mathematical methods to understand the unifying mechanisms more precisely, specifically in the areas of stem cell kinetics, metastasis, and immune response. In stem cell kinetics, his group has observed how cell killing can paradoxically cause promotion of a tumor (Hillen, Enderling, & Hahnfeldt, 2013). Similarly unexpected population dynamics have emerged in studies of tumor response to the immune system (Wilkie & Hahnfeldt, 2013). In addition, the Hahnfeldt group has proposed how two hallmarks of cancer previously thought to be distinct—metabolic reprogramming and immune action—are, in fact, quite interrelated (Kareva & Hahnfeldt, 2013).
Dr. Hahnfeldt is on the Editorial Board of Biology Direct and has served on Program and PI grant review committees for the National Institutes of Health (NIH), NASA, and the U.S. Department of Energy (DOE). He has also served as Executive Summary reviewer for the National Academies and as an advisor to the National Council on Radiological Protection and Measurements on methods of integrating low-dose radiation effects data into reliable predictive models of human health effects of exposure to low-dose radiation.
(click on title to go to manuscript abstract)
- Gao X, Sishc BJ, Nelson CB, Hahnfeldt P, Bailey SM, Hlatky
L. Radiation-Induced Reprogramming of Pre-Senescent Mammary
Epithelial Cells Enriches Putative CD44(+)/CD24(-/low) Stem Cell
Phenotype. Front Oncol. 2016 Jun 14;6:138. PMCID: PMC4905979. [Open Access]
- Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch
PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y,
Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL,
Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM. Evaluating biomarkers to model cancer risk post cosmic ray
exposure. Life Sci Space Res (Amst). 2016 Jun;9:19-47. Epub 2016 May 21. [Open Access]
- Benzekry S, Beheshti A, Hahnfeldt P, Hlatky
L. Capturing the driving role of tumor-host crosstalk in a
dynamical model of tumor growth. Bio Protocol. 2015 Nov
5;5(21). PMCID: PMC4957653. [Open Access]
- Beheshti A, Wage J, McDonald JT, Lamont C, Peluso M,
Hahnfeldt P, Hlatky L. Tumor-host signaling interaction reveals a
systemic, age-dependent splenic immune influence on tumor
development. Oncotarget. 2015 Nov 3;6(34):35419-32. Epub 2015 Oct 21. PMCID: PMC4742115. [Open Access]
- Wage J, Ma L, Peluso M, Lamont C, Evens AM, Hahnfeldt P,
Hlatky L, Beheshti A. Proton irradiation impacts age-driven modulations
of cancer progression influenced by immune system transcriptome
modifications from splenic tissue. J Radiat Res. 2015 Sep;56(5):792-803. Epub 2015 Aug 7. PMCID: PMC4577010. [Open
- Poleszczuk J, Hahnfeldt P, Enderling H. Therapeutic implications from
sensitivity analysis of tumor angiogenesis models. PLoS One. 2015 Mar
18;10(3):e0120007. PMCID: PMC4364928. [Open Access]
- Beheshti A, Benzekry S, McDonald JT, Ma L, Peluso
M, Hahnfeldt P, Hlatky L. Host age is a systemic regulator of gene expression impacting cancer progression. Cancer Res. 2015 Mar 15;75(6):1134-43. Epub 2015 Mar 2. PMCID: PMC4397972. [Open Access]
- Poleszczuk J, Hahnfeldt P, Enderling H. Evolution and phenotypic selection of
cancer stem cells. PLoS Comput Biol. 2015 Mar 5;11(3):e1004025. PMCID: PMC4351192. [Open Access]
- Kareva I, Wilkie KP, Hahnfeldt P. The Power of the Tumor Microenvironment: A Systemic Approach for a Systemic Disease. In: d'Onofrio A, Gandolfi A (eds). Mathematical Oncology 2013. Birkhäuser Basel, 2014:181-196. In Series: Modeling and Simulation in Science, Engineering and Technology: Bellomo N (series ed).
- Benzekry S, Gandolfi A, Hahnfeldt P. A mathematical model of systemic inhibition of angiogenesis
in metastatic development. Congrès SMAI
2013. ESAIM Proc Surv. 2014 Sept;45:75-87. Epub 2014 Nov 13. [Open
- Benzekry S, Lamont C, Beheshti A, Tracz A, Ebos JM,
Hlatky L, Hahnfeldt P. Classical mathematical models for
description and prediction of experimental tumor
growth. PLoS Comput Biol. 2014
Aug 28;10(8):e1003800. eCollection 2014. PMCID: PMC4148196. [Open Access]
- Weekes SL, Barker B, Bober S, Cisneros K, Cline J,
Thompson A, Hlatky L, Hahnfeldt P, Enderling H. A
multicompartment mathematical model of cancer stem cell-driven
tumor growth dynamics. Bull Math Biol. 2014 Jul;76(7):1762-82. Epub 2014 May 20. PMCID: PMC4140966.
- Poleszczuk J, Hahnfeldt P, Enderling H. Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence. Cell Prolif. 2014 Jun;47(3):267-76. Epub 2014 Mar 25.
- Gao X, McDonald JT, Naidu M, Hahnfeldt P, Hlatky
proposed quantitative index for assessing the potential
contribution of reprogramming to cancer stem cell kinetics. Stem
Cells Int. 2014 May 12;2014:249309. Epub 2014
Apr 17. PMCID: PMC4052692. [Open Access]
- Beheshti A, Peluso M, Lamont C, Hahnfeldt P, Hlatky L. Proton irradiation augments the suppression of tumor progression observed with advanced age. Radiat Res. 2014 Mar;181(3):272-83. Epub 2014 Feb 25. PMCID: PMC4406472. COVER ARTICLE
- Hlatky L, Hahnfeldt P. Beyond the cancer cell: progression-level determinants highlight the multi-scale nature of carcinogenesis risk. Cancer Res. 2014 Feb 1;74(3):659-64. Epub 2013 Nov 22. [Open Access]
- Benzekry S, Gandolfi A, Hahnfeldt P. Global dormancy of metastases due to systemic inhibition of angiogenesis. PLoS One. 2014 Jan 21;9(1):e84249. eCollection 2014. PMCID: PMC3897365. [Open Access]
- Rietman EA, Hahnfeldt P, Hlatky L. A Review
and Perspective on Thermodynamics Applied to Molecular Systems
and Cancer Biology. In: Valente AX, Sarkar A, Gao Y (eds). Recent Advances in Systems Biology
Research. Nova Science Publishers, Inc., 2014:49-78. In Series: Systems Biology — Theory, Techniques and Applications.
- Benzekry S, Hahnfeldt P. Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers. J Theor Biol. 2013 Oct 21;335:235-44. Epub 2013 Jul 11.
- Wilkie KP, Hahnfeldt P. Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion. Interface Focus. 2013 Aug 6;3(4):20130010. Epub 2013 Jun 25. PMCID: PMC3915830. [Open Access]
- Wilkie KP, Hahnfeldt P. Tumor–immune dynamics regulated in the microenvironment inform the transient nature of immune-induced tumor dormancy. Cancer Res. 2013 Jun 15;73(12):3534-44. Epub 2013 Mar 27. PMCID: PMC3955200. [Open Access]
- Rietman EA, Friesen DE, Hahnfeldt P, Gatenby R, Hlatky L, Tuszynski JA. An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis. Theor Biol Med Model. 2013 Jun 10;10(1):39. PMCID: PMC3689044. [Open Access]
- Wilkie KP, Hahnfeldt P. Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation. arXiv:1305.3634 [q-bio.CB]. 2013 May 15.
- Hahnfeldt P, Hlatky L, Klement GL. Center of Cancer
Systems Biology Second Annual Workshop — Tumor
Metronomics: Timing and Dose Level Dynamics. Cancer Res. 2013 May 15;73(10):2949-54. Epub 2013 Mar 14. PMCID: PMC3696500. [Open Access]
- Kareva I, Hahnfeldt P. The emerging “hallmarks” of metabolic reprogramming and immune evasion: distinct or linked? Cancer Res. 2013 May 1;73(9):2737-42. Epub 2013 Feb 19. [Open Access]
- Enderling H, Hlatky L, Hahnfeldt P. Cancer stem cells: a minor cancer subpopulation that redefines global cancer features. Front
Oncol. 2013 Apr 15;3:76. eCollection 2013. PMCID: PMC3625721. [Open Access]
- Beheshti A, Sachs RK, Peluso M, Rietman E, Hahnfeldt P, Hlatky L. Age and space irradiation modulate tumor progression:
implications for carcinogenesis risk. Radiat Res. 2013 Feb;179(2):208-20. Epub 2013 Jan 4.
- Hillen T, Enderling H, Hahnfeldt P. The tumor growth paradox and immune system-mediated selection for cancer stem cells. Bull Math Biol. 2013 Jan;75(1):161-84. Epub 2012 Nov 30.
- Hahnfeldt P. The host support niche as a control point for tumor dormancy: implications for tumor development and beyond. Adv Exp Med Biol. 2013;734:19-35. (also in Systems Biology of Tumor Dormancy. Enderling H,
Almog N, Hlatky L, editors. New York: Springer, 2013:19-35.)
- Enderling H, Hlatky L, Hahnfeldt P. Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth. Theor Biol Med Model. 2012 Jul 28;9(1):31. Epub 2012 Jul 28. PMCID: PMC3499182. [Open Access]
- Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L. Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth. Radiat Res. 2012 Jul;178(1):33-45. Epub 2012 Jun 14.
- Enderling H, Hahnfeldt P, Hlatky L, Almog N. Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy. Cancer Res. 2012 May 1;72(9):2172-5. Epub 2012 Mar 13. PMCID: PMC3374524. [Open Access]
- Enderling H, Hlatky L, Hahnfeldt P. The promoting
role of a tumour-secreted chemorepellent in self-metastatic
tumour progression. Math Med Biol. 2012 Mar;29(1):21-9. Epub 2010 Oct 6.
- Morton CI, Hlatky L, Hahnfeldt P, Enderling
H. Non-stem cancer cell kinetics modulate solid tumor
progression. Theor Biol Med Model. 2011 Dec 30;8:48. PMCID: PMC3285090. [Open Access]
- Enderling H, Hahnfeldt P. Cancer stem cells in solid tumors: is ‘evading apoptosis’ a hallmark of cancer? Prog Biophys Mol Biol. 2011 Aug;106(2):391-9. Epub 2011 Apr 5.
- Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L. A multicellular basis for the origination of
blast crisis in chronic myeloid leukemia. Cancer
Res. 2011 Apr 15;71(8):2838-47. Epub 2011 Apr 12. PMCID: PMC3537493. [Open Access]
- Enderling H, Chaplain MA, Hahnfeldt P. Quantitative modeling of tumor dynamics and radiotherapy. Acta Biotheor. 2010 Dec;58(4):341-53. Epub 2010 Jul 24.
- Hahnfeldt P. Significance of tumor self-seeding as an augmentation to the classic metastasis paradigm. Future Oncol. 2010 May;6(5):681-5. [Open Access]
- Enderling H, Hlatky L, Hahnfeldt P. Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype. Biol Direct. 2010 Apr 20;5:23. PMCID: PMC2868833. [Open Access]
- Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 2009 Nov 15;69(22):8814-21. Epub 2009 Nov 3. [Open Access]
- Fakir H, Tan WY, Hlatky L, Hahnfeldt P, Sachs RK. Stochastic population dynamic effects for lung cancer progression. Radiat Res. 2009 Sep;172(3):383-93.
- Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner, DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys. 2009 Aug;48(3):263-74. Epub 2009 Jun 18. PMCID: PMC2714893. [Open Access]
- Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner, DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 2009 Aug;48(3):275-86. Epub 2009 Jun 5. PMCID: PMC2714894. [Open Access]
- Enderling H, Hlatky L, Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer. 2009 Jun 16;100(12):1917-25. Epub 2009 May 19. PMCID: PMC2714240. [Open Access]
- Enderling H, Park D, Hlatky L, Hahnfeldt P. The importance of spatial distribution of stemness and proliferation state in determining tumor radioresponse. Math Model Nat Phenom. 2009 Jan;4(03):117-33.
- Feinendegen L, Hahnfeldt P, Schadt EE, Stumpf M, Voit EO. Systems biology and its potential role in radiobiology. Radiat Environ Biophys. 2008 Feb;47(1):5-23. Epub 2007 Dec 18.
- Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 7;249(3):518-31. Epub 2007 Aug 12. PMCID: PMC2169295.
- Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE. Transcriptional network governing the angiogenic switch in human pancreatic cancer. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. PMCID: PMC1931565. [Open Access]
- Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA. Subtraction of background damage in PFGE experiments on DNA fragment-size distributions. Radiat Environ Biophys. 2007 Jun;46(2):155-60.
- Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806. [Open Access]
- Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA. A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions. Radiat Res. 2006 Dec;166(6):908-16.
- Sachs RK, Chan M, Hlatky L, Hahnfeldt P. Modeling intercellular interactions during carcinogenesis. Radiat Res. 2005 Sep;164(3):324-31.
- Plan Y, Hlatky L, Hahnfeldt P, Sachs R, Loucas B, Cornforth M. Full-color
painting reveals an excess of radiation-induced dicentrics involving homologous
chromosomes. Int J Radiat Biol. 2005 Aug;81(8):613-20.
- Arsuaga J, Greulich-Bode KM, Vazquez M, Bruckner M, Hahnfeldt P, Brenner DJ,
Sachs R, Hlatky L. Chromosome spatial clustering inferred from radiogenic
aberrations. Int J Radiat Biol. 2004 Jul;80(7):507-15.
- Abdollahi A, Hahnfeldt P, Maercker C, Gröne HJ, Debus J, Ansorge W, Folkman J, Hlatky L, Huber PE. Endostatin's antiangiogenic signaling network. Mol Cell. 2004 Mar 12;13(5):649-63. [Open Access]
- Sachs RK, Levy D, Hahnfeldt P, Hlatky L. Quantitative analysis of radiation-induced chromosome aberrations. Cytogenet Genome Res.
- Abdollahi A, Lipson KE, Sckell A, Zieher H, Klenke F, Poerschke D, Roth A, Han
X, Krix M, Bischof M, Hahnfeldt P, Grone HJ, Debus J, Hlatky L, Huber PE. Combined therapy with direct and indirect angiogenesis inhibition results in
enhanced antiangiogenic and antitumor effects. Cancer Res. 2003 Dec
15;63(24):8890-8. [Open Access]
- Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P,
Hlatky L, Debus J, Howlett AR, Huber PE. SU5416 and SU6668 attenuate the
angiogenic effects of radiation-induced tumor cell growth factor production and
amplify the direct anti-endothelial action of radiation in vitro. Cancer Res.
2003 Jul 1;63(13):3755-63. [Open Access]
- Hahnfeldt P, Folkman J, Hlatky L. Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis. J Theor Biol. 2003 Feb 21;220(4):545-54.
- Vazquez M, Greulich-Bode KM, Arsuaga J, Cornforth MN, Brückner M, Sachs RK,
Hlatky L, Molls M, Hahnfeldt P. Computer analysis of mFISH chromosome aberration data uncovers an excess of very complicated metaphases. Int J Radiat Biol. 2002 Dec;78(12):1103-15. [Open Access]
- Sachs R, Arsuaga J, Vázquez M, Hlatky L, Hahnfeldt P. Using graph theory to describe and model chromosome aberrations. Radiat Res. 2002 Nov;158(5):556-67.
- Cornforth MN, Greulich-Bode KM, Loucas BD, Arsuaga J, Vázquez M, Sachs RK,
Brückner M, Molls M, Hahnfeldt P, Hlatky L, Brenner DJ. Chromosomes are
predominantly located randomly with respect to each other in interphase human
cells. J Cell Biol. 2002 Oct 28;159(2):237-44. Epub 2002 Oct 28. PMCID: PMC2173058. [Open Access]
- Panigrahy D, Singer S, Shen LQ, Butterfield CE, Freedman DA, Chen EJ, Moses
MA, Kilroy S, Duensing S, Fletcher C, Fletcher JA, Hlatky L, Hahnfeldt P, Folkman
J, Kaipainen A. PPARγ ligands inhibit primary tumor growth and metastasis by
inhibiting angiogenesis. J Clin Invest. 2002 Oct;110(7):923-32. PMCID: PMC151148. [Open Access]
- Browder T, Folkman J, Hahnfeldt P, Heymach J, Hlatky L, Kieran M, Rogers MS. Antiangiogenic therapy and p53. Science. 2002 Jul 26;297(5581):471; discussion 471. [Open Access]
- Hlatky L, Hahnfeldt P, Folkman J. Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst. 2002 Jun 19;94(12):883-93. [Open Access]
- Sachs RK, Hlatky LR, Hahnfeldt P. Simple ODE models of tumor growth and anti-angiogenic or radiation treatment. Mathematical and Computer Modelling. 2001 Jun;33(12-13):1297-305. [Open Access]
- Signoretti S, Montironi R, Manola J, Altimari A, Tam C, Bubley G, Balk S,
Thomas G, Kaplan I, Hlatky L, Hahnfeldt P, Kantoff P, Loda M. Her-2-neu
expression and progression toward androgen independence in human prostate cancer.
J Natl Cancer Inst. 2000 Dec 6;92(23):1918-25. [Open Access]
- Sachs RK, Levy D, Chen AM, Simpson PJ, Cornforth MN, Ingerman EA, Hahnfeldt P,
Hlatky LR. Random breakage and reunion chromosome aberration formation model; an
interaction-distance version based on chromatin geometry. Int J Radiat Biol. 2000
- Folkman J, Hahnfeldt P, Hlatky L. Cancer: looking outside the genome. Nat Rev Mol Cell Biol. 2000 Oct;1(1):76-9.
- Sachs RK, Rogoff A, Chen AM, Simpson PJ, Savage JR, Hahnfeldt P, Hlatky LR. Underprediction of visibly complex chromosome aberrations by a
recombinational-repair (‘one-hit’) model. Int J Radiat Biol. 2000
- Hahnfeldt P, Panigrahy D, Folkman J, Hlatky L. Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res. 1999 Oct 1;59(19):4770-5. [Open Access]
- Sachs RK, Ponomarev AL, Hahnfeldt P, Hlatky LR. Locations of
radiation-produced DNA double strand breaks along chromosomes: a stochastic
cluster process formalism. Math Biosci. 1999 Jul;159(2):165-87.
- Sachs RK, Chen AM, Simpson PJ, Hlatky LR, Hahnfeldt P, Savage JR. Clustering
of radiation-produced breaks along chromosomes: modelling the effects on
chromosome aberrations. Int J Radiat Biol. 1999 Jun;75(6):657-72.
- Hardenbergh PH, Hahnfeldt P, Hlatky L, Takemoto C, Shimamura A, McGill G, Fung CY, Bodis S, Fisher DE. Distinct mathematical behavior of apoptotic versus
non-apoptotic tumor cell death. Int J Radiat Oncol Biol Phys. 1999 Feb
- Hahnfeldt P, Hlatky L. Cell resensitization during protracted dosing of heterogeneous cell populations. Radiat Res. 1998 Dec;150(6):681-7.
- Sachs RK, Brenner DJ, Hahnfeldt PJ, Hlatkys LR. A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes. Int J Radiat Biol. 1998 Aug;74(2):185-206.
- Brenner DJ, Hlatky LR, Hahnfeldt PJ, Huang Y, Sachs RK. The linear-quadratic
model and most other common radiobiological models result in similar predictions
of time-dose relationships. Radiat Res. 1998 Jul;150(1):83-91.
- Radivoyevitch T, Hoel DG, Hahnfeldt P, Sachs RK. Size distributions of
misrejoining DNA fragments in irradiated cells. Math Biosci. 1998
- Radivoyevitch T, Hoel DG, Hahnfeldt PJ, Rydberg B, Sachs RK. Recent data
obtained by pulsed-field gel electrophoresis suggest two types of double-strand
breaks. Radiat Res. 1998 Jan;149(1):52-8.
- Sachs RK, Brenner DJ, Chen AM, Hahnfeldt P, Hlatky LR. Intra-arm and interarm chromosome intrachanges: tools for probing the geometry and dynamics of
chromatin. Radiat Res. 1997 Oct;148(4):330-40.
- Sachs RK, Hahnfeld P[sic], Brenner DJ. The link between low-LET dose-response
relations and the underlying kinetics of damage production/repair/misrepair. Int
J Radiat Biol. 1997 Oct;72(4):351-74.
- Magi-Galluzzi C, Xu X, Hlatky L, Hahnfeldt P, Kaplan I, Hsiao P, Chang C, Loda M. Heterogeneity of androgen receptor content in advanced prostate cancer. Mod Pathol. 1997 Aug;10(8):839-45.
- Brenner DJ, Hahnfeldt P, Amundson SA, Sachs RK. Interpretation of inverse dose-rate effects for mutagenesis by sparsely ionizing radiation. Int J Radiat
Biol. 1996 Oct;70(4):447-58.
- Hlatky L, Hahnfeldt P, Tsionou C, Coleman CN. Vascular endothelial growth factor: environmental controls and effects in angiogenesis. Br J Cancer Suppl. 1996 Jul;27:S151-6. PMCID: PMC2149987.
- Hlatky L, Olesiak M, Hahnfeldt P. Measurement of potential doubling time for
human tumor xenografts using the cytokinesis-block method. Cancer Res. 1996 Apr
1;56(7):1660-3. [Open Access]
- Hahnfeldt P, Hlatky L. Resensitization due to redistribution of cells in the phases of the cell cycle during arbitrary radiation protocols. Radiat Res. 1996 Feb;145(2):134-43.
- Brenner DJ, Hlatky LR, Hahnfeldt PJ, Hall EJ, Sachs RK. A convenient extension of the linear-quadratic model to include redistribution and reoxygenation. Int J Radiat Oncol Biol Phys. 1995 May 15;32(2):379-90.
- Hlatky L, Van Buren T, Hahnfeldt P. Quantifying intracellular radioresponse
diversity in irradiated sandwich cultures via micronucleus expression. Int J
Radiat Biol. 1995 May;67(5):541-8.
- Hahnfeldt P, Hlatky LR, Brenner DJ, Sachs RK. Chromosome aberrations produced by radiation: the relationship between excess acentric fragments and dicentrics. Radiat Res. 1995 Feb;141(2):136-52.
- Hlatky L, Tsionou C, Hahnfeldt P, Coleman CN. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial
growth factor up-regulation and protein expression. Cancer Res. 1994 Dec
1;54(23):6083-6. [Open Access]
- Hlatky LR, Hahnfeldt P, Sachs RK. Influence of time-dependent stochastic heterogeneity on the radiation response of a cell population. Math Biosci. 1994 Aug;122(2):201-20.
- Hahnfeldt P, Hlatky LR. A Monte Carlo/Markov chain model for the association of data for chromosome aberrations and formation of micronuclei. Radiat Res. 1994 May;138(2):239-45.
- Kruskal JB, Hlatky L, Hahnfeldt P, Teramoto K, Stokes KR, Clouse ME. In vivo and in vitro analysis of the effectiveness of doxorubicin combined with temporary arterial occlusion in liver tumors. J Vasc Interv Radiol. 1993 Nov-Dec;4(6):741-7.
- Hahnfeldt P, Hearst JE, Brenner DJ, Sachs RK, Hlatky LR. Polymer models for interphase chromosomes. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7854-8. PMCID: PMC47241. [Open Access].
- Sachs RK, Chen P, Hahnfeldt P, Lai D, Hlatky LR. DNA damage in non-proliferating cells subjected to ionizing irradiation at high or low dose rates. J Math Biol. 1993;31(3):291-315.
- Sachs RK, Chen PL, Hahnfeldt PJ, Hlatky LR. DNA damage caused by ionizing radiation. Math Biosci. 1992 Dec;112(2):271-303.
- Hlatky LR, Sachs RK, Hahnfeldt P. The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation. Radiat Res. 1992 Mar;129(3):304-8.
- Hahnfeldt P, Sachs RK, Hlatky LR. Evolution of DNA damage in irradiated cells. J Math Biol. 1992;30(5):493-511.
- Hlatky L, Sachs R, Hahnfeldt P. Reaction kinetics for the development of radiation-induced chromosome aberrations. Int J Radiat Biol. 1991
- Sachs RK, Hlatky L, Hahnfeldt P, Chen PL. Incorporating dose-rate effects in Markov radiation cell survival models. Radiat Res. 1990 Nov; 124(2):216-26.